Screamin' Eagle Twin Cam Performance Cams- SE-259E

Part Number 25482-10




Camshafts are a fundamental ingredient in the performance recipe, because they control the timing and duration of all major engine events. They are the primary means by which you can tune your engine’s horsepower and torque output. Every cam has unique lift and overlap performance characteristics, which means you need to select cams based on exactly the kind of power you’re looking for.

  • Developed specifically for throttle body EFI systems, this cam has a modern lobe design that allows for higher valve lifts for a given duration
  • A high-lift version of the SE-211 camshaft, this cam works great with 103 cubic inch and larger engines with free-flowing intake and exhaust
  • Can be used with stock heads (updated with race springs) and high-compression pistons for even more torque than a SE-211 cam, or can be coupled with any of the performance heads to realize the full power potential
  • Kit includes front and rear cams
  • Splined rear cam is included for exceptional load handling capability
  • Gaskets and bearings not included
  • Dealer installation is recommended and special tools are required for proper installation
  • All EFI models require ECM calibration

For use on ’11-’15 103CI and 110CI Touring and Trike models. Installation requires separate purchase of Performance Valve Spring Kit P/N 18013-03A. All models require ECM calibration for proper installation. Labor cost not included. See Dealer for details.

Bike not listed?
Select your year and model to see all the parts that fit your bike.

  • Model
  • These Screamin' Eagle® products are 50-state street-legal for sale and use on all vehicles, including those that are pollution controlled. Complies with the requirements of 40 CFR Part 86, subparts E and F.


Separate purchase of Cam Drive Retention Kit P/N 25566-06 and Cam Spacer Kit P/N 25928-06 may be required. These kits contain five different spacers to achieve proper sprocket alignment. Individual spacers can be purchased separately.

  • Dealer Install Recommended

  • Warranty

    1 year limited warranty – Go to for full details
  • Requires ECM Calibration

  • Sold in Unit

  • In The Box

    Front and rear cams
  • Sold Separately

    Gaskets and bearings
  • Upgrade Stage Level

    Stage II
Performance Cams - SE-259E is rated 5.0 out of 5 by 1.
Rated 5 out of 5 by from Very good all around power I have this cam as part of a stage 4 kit. It has very good pull over the entire rpm range.
Date published: 2014-08-18
  • y_2018, m_2, d_26, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.7
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_PA-18-2548210, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING), SortEntry(order=FEATURED, direction=DESCENDING), SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_harleydavidson

What ECM MAP is better for my CVO Breakout?

I have this cam as a part of SCREAMIN EAGLE PRO STAGE 3 RACE KIT Part. N. 27548-10A. Installed on my 2014 CVO Breakout. What kind of MAP i have to load with the SEST? What file do You suggest?
Asked by: Elias2001

will i have to change the valve spings on a 2015 CVO 110 street gilde for a SE 259 cams

Asked by: Madmax

i own a 2015 cvo 110 street glide that has SE-255 cams, what gains will i get installing SE-259 cams

im looking for all around more power gains mostly top end!
Asked by: Madmax

what sould thisSE-259E give my 2015 CVO 110 street glige for torque and horsepower

Asked by: Madmax

se285 new cams and 16500208 heads

will the 16500208 heads work with a 110 kit as well as the new 285 cams.? thanks in advance, rick
Asked by: freonjocke
Hello Freonjocke, At this time, this combination has not been tested together, so we do not know if they will work together. Please consult your local dealership to see if they have tried this combination and what their results were. Thank You!
Answered by: JD34
Date published: 2015-04-22
  • y_2018, m_2, d_26, h_20CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.7
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_6
  • loc_en_US, sid_PA-18-2548210, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_harleydavidson

Recently Viewed

    Please Hold Your Iron Horses

    You've been sitting idle, so we've ended your session to protect your personal details.

    Continue as guest Sign in
    Online Exclusives

    You’ve been sitting idle, so your session will expire in

    Would you like to remain signed in and continue shopping?

    Yes, keep me signed in No, sign me out

    Prices listed are generally the Manufacturer's Suggested Retail Price (MSRP), excluding taxes and shipping. Prices at local dealerships may vary. All online orders will be fulfilled and shipped by
    Harley-Davidson Motor Company as the agent for the Selling Dealer.